Abstrait

An Overview of Nano diamond Formulation in Cancer Treatment

Ankit Majie

The major challenge of cancer chemotherapy is the improvement of systemic bioavailability, targeted drug delivery, reduced off-target activity, Enhanced Permeation and Retention Effect (EPR), sustained, and controlled release profiles. Most current conventional drug delivery systems cannot optimize the above mentioned problems, leading to chemotherapeutic resistance. More studies are being conducted on novel delivery systems to overcome these problems. One such system is the nano diamond formulation. Nano diamonds not only overcome these problems but also increase cytotoxicity, stimulate the immune system, prevent metastasis, decrease resistance, and optimize the formulation's pharmacodynamic properties. The unique surface chemistry of the particle allows easy modification of the outer layer with different functional groups to enhance the receptor-ligand interaction. The property of self-assembling into aggregates of a suitable size range makes it ideal for controlled and sustained drug delivery. However, much clinical investigation is required on the safety profile of the formulation for chronic use.