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Antidiarrhoeal Effects of Ethanolic Extract of Unripe fruit of Aegle Marmelos (Bael) in Mice

Manjunath V Jali, Nirmala P, Annamalai AR, and Basavaraj KM

This present study was undertaken to investigate antidiarrhoeal activity of ethanolic extract of unripe fruit of Aegle marmelos (EEAM) in castor oil, prostaglandin E2 (PGE2), 5-Hydroxytryptamine (5-HT), and carbachol induced diarrhoea in mice. The higher dose of EEAM (800mg/kg) completely prevented the diarrhoea whereas the lower doses (200 and 400mg/kg) significantly increased the time of induction of diarrhea, decreased the number and weight of wet faeces in castor oil induced diarrhoea. The higher doses of EEAM (400 and 800 mg/kg) significantly increased time of induction of diarrhoea, decreased the number and weight of wet faeces in PGE2, 5-HT and carbachol induced diarrhoea, whereas lower doses had no effect on these parameters.