Jugasmita Khatua, K Vanitha Prakash, G Manasa, and R Praveena
A simple, accurate, sensitive and reproducible visible spectrophotometric method has been developed for the determination of Gliclazide in bulk and also in its pharmaceutical dosage form. The proposed method was based on ion-complex of the drug with Bromo Cresol Green showing absorbance maxima at 411 nm respectively. Beer's law was obeyed in the range of 50-300 μg/mL , with molar absorptivity 1.044x 103 L.mol-1cm-1, relative standard deviation of the method was less than 1% and accuracy (average recovery %) was 94. All the variables were studied to optimize the reaction conditions. No interference was observed in the presence of common pharmaceutical excipients. The validity of the methods was tested by analyzing the drug in its pharmaceutical preparations. Good recoveries were also obtained. The developed method employed was successful for the determination of Gliclazide in various pharmaceutical preparation.
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