Abstrait

Nodolase: A Review of Efficacy

Massimo Sarracino

NODOLASETM it’s a new dietary supplement formulated with natural active and characterized by anti-inflammatory, anti-edema, analgesic and anti-oxidant effects. The aim of this review was to report the efficacy of NODOLASETM in several patients. NODOLASETM has been studied in patients with joint, tendons and muscle diseases, acute exacerbations of COPD and dental disease. In patients with wrist, ankle and knee sprain or with muscle strain as well as after plaster cast removal, NODOLASETM resulted in a good efficacy in reducing pain and swelling. Furthermore, NODOLASETM was able to significantly improve the joint function by a significant reduction of stiffness of at least 30% in all studies. In patients with mild to moderate acute exacerbations of COPD, NODOLASETM has been added to the antibiotic therapy. However, compared to the broad-spectrum antibiotic therapy alone, the combination with NODOLASETM has resulted in a faster improvement of cough and dyspnea. The results of this study showed that the antibiotic association with NODOLASETM was able to improve better the respiratory function (FEV1) compared to antibiotic monotherapy. Also extremely important the addition of NODOLASETM has determined a higher impact on the inflammatory pattern and in particular on IL-6, IL-8 and TNF-alpha in comparison to the antibiotic alone. NODOLASETM in combination with analgesic in patients undergoing wisdom teeth has been investigated in a randomized study. In comparison with a traditional analgesic for 7 days the group treated with the combination NODOLASETM+analgesic achieved better results in terms of efficacy with a lower incidence of pain local recurrence as well as a better recovery of the mandibular function. No adverse effects due to the administration of NODOLASETM were reported. Treatment with NODOLASETM was evaluated safe in all studies both by clinicians and patients.