Abstrait

Simultaneous Spectrophotometric Estimation of Albendazole and Ivermectin in Pharmaceutical Formulation.

Rajiv Kumar Chomwal, and Anju Goyal

The study aim to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation on albendazole and ivermectin in tablet dosage forms. Pure drug sample of albendazole and ivermectin were dissolved in a mixture of methanol and 1 N HCl (70:30). Two wavelengths selected for formation and solving the simultaneous equations were 248.8 nm for albendazole and 314.4 nm for ivermectin. Absorptivity coefficients for albendazole at 248.8 and 314.4 nm were 63.22 cm-1g-1L and 30.31 cm-1g-1L respectively, while the respective values for ivermectin were 41.59 cm-1g-1L and 23.19 cm-1g-1L. The recovery studies were found close to 100 % that indicates accuracy and precision of proposed method. The statistical analysis was carried out and results of which were found satisfactory. Standard deviation values were found low that indicated reproducibility of proposed method. Based on results the developed method could be used for routine estimation of albendazole and ivermectin from combined dosage formulations.