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Spectrophotometric Method Development and Validation of Valacyclovir Hydrochloride in Bulk and Pharmaceutical Dosage Form

VMK Gowtam Potnuru, Krishna Reddy Y, Arjun CH, Prasanthi P, Ramya Krishna M, and Chandra Sekhar E

A simple, accurate, precise UV spectrophotometric method was developed in pure and pharmaceutical formulations for Valacyclovir hydrochloride. It is a antiviral drug. Valacyclovir hydrochloride exhibiting maximum absorbance at 255 nm in 0.1 M sulphuric acid and the method was validated for linearity, precision, sensitivity, and specificity. The drug obeyed linearity at concentration range of 4–12 μg/ml. The proposed method was validated statistically with significant high value of correlation coefficient 0.999. The percentage recovery value for Valacyclovir hydrochloride was in the range of 99.4 – 100.9 %. Therefore, the proposed method could be applied for the routine analysis of pharmaceutical dosage forms containing Valacyclovir hydrochloride.