Ragab R Amin, Mohammed Abo-Elkassem and Alaa Anwar
The 1:1 and 2:1 M ratio metal complexes of new Cu(II), Co(II), Fe(III), Zn(II) and Zr(II) complexes of Oxytetracycline hydrochloride have been synthesized. Attempts have been made to ascertain their probable structures based on elemental analysis, spectra (IR, Electronic) and NMR studies. The ligand form a complex in a molar ratio 1:1 having an empirical formula (MLSO4.nH2O) and 2:1 molar ratio having an empirical formula (M2LSO4.nH2O) where M=Cu(II), Co(II), Fe(III), Zn(II) and Zr(II), L=Oxytetracycline and n=2-6. The infrared spectral data and NMR studies were support the postulate that oxytetracycline reacts with metal ions as an ionic bidentate ligand through its carboxylate oxygen and the amide carbonyl oxygen. The antibacterial evaluation of the Oxytetracycline drug and their complexes were also performed against some gram positive and negative bacteria as well as fungi.