Abstrait

TRP Gene Family as a Prognostic Marker for Kidney Renal Clear Cell Carcinoma: Analysis of TCGA Data

Jiaxin Wang1,2, Xin Zhang1,2, Renhui Xiong1,2, Qian Zhang1,2, Zhong Luo1,2, Guyue Hu1,4, Lei Niu1,2,3*

The Transient Receptor Potential (TRP) channels are a group of gated cation channels with multiple activation properties. The connection between the TRP gene family and tumor progression has been identified. It is still unclear, nevertheless, how they influence the progression and prognosis of Kidney renal clear cell carcinoma (KIRC). Single- and multifactor analyses of KIRC patients’ data from The Cancer Genome Atlas (TCGA) database were performed, and the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was established and tested. The changes in TRP family expression have been investigated through tumor stages to determine whether they associate with poor outcomes. Analyze functional enrichment of essential TRP members. Our results revealed TRP gene family could be used as an essential prognostic marker in KIRC. Additionally, an abnormally high expression of TRPV3 has a strong connection with a poor prognosis and could shorten the survival time of patients and lead to the cancer progression.